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KMID : 0376219710080010119
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Chonnam Medical Journal
1971 Volume.8 No. 1 p.119 ~ p.128
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Studies on the distribution of different adrenotropic receptors in the urinary bladder of the rabbits
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Abstract
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It has been known that the urinary bladder is innervated by jarasympathetic and sympathetic nerues. However, the physiological significance of the sympathetic supply to the bladder has not been clearly elucidated. In this experiment, responses of isolated strips of various portions of rabbit bladder to some autonomic drugs were observed to examine the existence of the adrenergic nerve fibers and distribution of different adrenotropic receptors in the urinary bladder.
Muscle strips taken from the trigone and the adjacent area to trigone and internal urethral orifice responded with contraction to catecholamnine (norepinephrine and epinephrine) and this response was not affected by pretreatment with dichloroisoproterenol, a beta-receptor blocking agent, whereas it was completely abolished by pretreatment of regitine or phenoxybenzamine, alpha-receptor blocking agents. The strips of detrusor muscle from the fundus responded with relaxation to catecholamine and this response was not affected by pretreatment of regitine or phenoxybenzamine, whereas it was completely abolished by pretreatment with dichloroisoproterenol.
These experimental evidences indicate that entire urinary bladder is innervated by adrenergic nerve fibers and that adrenotropic receptors in the trigone muscle and in adjacent portion of detrusor to the trigone and internal urethral orifice are of alpha type, whereas receptors in the remaining portion of detrusor muscle are of beta-type. It is suggested that the distribution of different adrenotropic receptors in the urinary bladder does not exactly coincide with anatomical demarcation such as Trigonum vesicae and Detrusor vesicae.
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